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KMID : 0382619910110010507
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Hanyang Journal of Medicine
1991 Volume.11 No. 1 p.507 ~ p.515
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Oligo-2´-5´-Adenylate Synthetase Activity in HBsAg-Seronegative healthy Korean, HBsAg-Seropositive and Cancer Patients
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金種穗/Kim, Jong Soo
鄭和順/金春元/Chung, Wha Soon/Kim, Choon Won
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Abstract
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Interferon(IFN) have revealed evidence that have cellular proliferation regulatory, immunoregulatory, antitumor and antiviral functions. Furthermore, interferon has the capacity to induce oligo-2´-5´-adenylate synthetase(2-5AS), which plays an important role in the antiviral fiulction in cultured cells and peripheral blood mononuclear leukocyte.
2-5AS is induced by interferon and it´s activity in mononuclear cells reliably reflects activation of the IFN system by viral infections. RIA kit was used for establishment of Korean normal serum level of 36 healthy HBsAg seronegative subjects (male 21, female 15), 19 HBsAg seropositive patients and 20 cancer patients (hepatic carcinolma and colon carcinoma) were examined , respectively.
The following results were obtained.
1. HBsAg negative healthy adult normal individuals were 40.39±41.30 pmol/dl.
2. HBsAg seropositive individuals were 48.44±47.46 pmol/dl.
3, Carcinoma patients were 37.66±36.02 pmol/dl.
In conclusion, serum 2-5AS plays an important role in the detection of viral infections, but clinical usefulness and application of the test for laboratory diagnosis should be more evaluated.
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KEYWORD
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